Anyone with admin rights to affect user accounts or anything security related, including Chrome settings, should already have forced 2FA.
This change shouldn't be a problem for anyone.
If it is, then you've always been doing it wrong, and it's about time it's corrected.
However, Google also put some dumb features as admin roles instead of Apps Settings. So my first sentence here is a little bit relevant.
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https://wheretofind.me/@NoSubstitute